Clinical significance of intronic variants in BRAF inhibitor resistant melanomas with altered BRAF transcript splicing

• Main Authors: Gulietta M. Pupo (Author), Suzanah C. Boyd (Author), Carina Fung (Author), Matteo S. Carlino (Author), Alexander M. Menzies (Author), Bernadette Pedersen (Author), Peter Johansson (Author), Nicholas K. Hayward (Author), Richard F. Kefford (Author), Richard A. Scolyer (Author), Georgina V. Long (Author), Helen Rizos (Author)
• Format: Book
• Published: BMC, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Alternate BRAF splicing is the most common mechanism of acquired resistance to BRAF inhibitor treatment in melanoma. Recently, alternate BRAF exon 4-8 splicing was shown to involve an intronic mutation, located 51 nucleotides upstream of BRAF exon 9 within a predicted splicing branch point....