Engineering extracellular vesicles with macrophage membrane fusion for ameliorating imiquimod-induced psoriatic skin inflammation

• Main Authors: Zeng Wang (Author), Zhizhen Qin (Author), Jiadie Wang (Author), Xinqi Xu (Author), Mengxin Zhang (Author), Yuyue Liang (Author), Yukun Huang (Author), Zengyang Yu (Author), Yu Gong (Author), Luxian Zhou (Author), Yiran Qiu (Author), Minglu Ma (Author), Dan Li (Author), Bin Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction Herein, we developed an engineered extracellular vehicle (EV)-based method for ameliorating inflammatory responses in psoriasis. Methods EVs, derived from annexin A1 (ANXA1) overexpressing T cells, were co-extruded with M2 macrophage membrane to obtain engineered EVs. In vitro, the effe...