Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia

• Main Authors: Claudio Nardiello (Author), Ivana Mižíková (Author), Diogo M. Silva (Author), Jordi Ruiz-Camp (Author), Konstantin Mayer (Author), István Vadász (Author), Susanne Herold (Author), Werner Seeger (Author), Rory E. Morty (Author)
• Format: Book
• Published: The Company of Biologists, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Progress in developing new therapies for bronchopulmonary dysplasia (BPD) is sometimes complicated by the lack of a standardised animal model. Our objective was to develop a robust hyperoxia-based mouse model of BPD that recapitulated the pathological perturbations to lung structure noted in infants...