GPNMB-Positive Cells in Head and Neck Squamous Cell Carcinoma-Their Roles in Cancer Stemness, Therapy Resistance, and Metastasis

• Main Authors: Yohei Kawasaki (Author), Hitomi Suzuki (Author), Shinsuke Suzuki (Author), Takechiyo Yamada (Author), Maya Suzuki (Author), Ayumi Ito (Author), Haruka Hatakeyama (Author), Masahito Miura (Author), Yasufumi Omori (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Despite the use of surgical and chemoradiation therapies, head and neck squamous cell carcinoma (HNSCC) still has a poor prognosis. Immune checkpoint inhibitors have been shown to prolong life expectancy but have limited efficacy. Glycoprotein nonmetastatic melanoma protein B (GPNMB) has...