Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson's disease models in vitro and vivo

• Main Authors: Hongzhi Li (Author), Bohao Sun (Author), Yuting Huang (Author), Jing Zhang (Author), Xuejing Xu (Author), Yuqi Shen (Author), Zhuo Chen (Author), Jifeng Yang (Author), Luxi Shen (Author), Yongwu Hu (Author), Haihua Gu (Author)
• Format: Book
• Published: BMC, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Purpose Parkinson's disease (PD) is the second most common neurodegenerative disease without cure or effective treatment. This study explores whether the yeast internal NADH-quinone oxidoreductase (NDI1) can functionally replace the defective mammalian mitochondrial complex I, which ma...