Comparison of fully-automated radiosyntheses of [11C]erlotinib for preclinical and clinical use starting from in target produced [11C]CO2 or [11C]CH4

• Main Authors: Cécile Philippe (Author), Severin Mairinger (Author), Verena Pichler (Author), Johann Stanek (Author), Lukas Nics (Author), Markus Mitterhauser (Author), Marcus Hacker (Author), Thomas Wanek (Author), Oliver Langer (Author), Wolfgang Wadsak (Author)
• Format: Book
• Published: SpringerOpen, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background [11C]erlotinib has been proposed as a PET tracer to visualize the mutational status of the epidermal growth factor receptor (EGFR) in cancer patients. For clinical use, a stable, reproducible and high-yielding radiosynthesis method is a prerequisite. In this work, two production...