Study and ICH validation of a reverse-phase liquid chromatographic method for the quantification of the intact monoclonal antibody cetuximab

• Main Authors: Antonio Martínez-Ortega (Author), Agustín Herrera (Author), Antonio Salmerón-García (Author), José Cabeza (Author), Luis Cuadros-Rodríguez (Author), Natalia Navas (Author)
• Format: Book
• Published: Elsevier, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cetuximab (CTX) is a potent chimeric mouse/human monoclonal antibody (mAb) approved worldwide for treatment of metastatic colorectal cancer. Among the various biological and physical analyses performed for full study on this biopharmaceutic, the determination of the concentration preparations throug...