Distinction between 2'- and 3'-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration

• Main Authors: Raoul Manuel (Author), Michelle de Souza Lima (Author), Sébastien Dilly (Author), Sylvain Daunay (Author), Patricia Abbe (Author), Elodie Pramil (Author), Stéphanie Solier (Author), Fabienne Guillaumond (Author), Sarah-Simha Tubiana (Author), Alexandre Escargueil (Author), João Antonio Pêgas Henriques (Author), Nathalie Ferrand (Author), Irène Erdelmeier (Author), Jean-Luc Boucher (Author), Gildas Bertho (Author), Israel Agranat (Author), Stéphane Rocchi (Author), Michèle Sabbah (Author), Anny Slama Schwok (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Specific inhibition of NADPH oxidases (NOX) and NO-synthases (NOS), two enzymes associated with redox stress in tumor cells, has aroused great pharmacological interest. Here, we show how these enzymes distinguish between isomeric 2'- and 3'-phosphate derivatives, a difference used to impro...