Bioreduction of Idarubicin and Formation of ROS Responsible for DNA Cleavage by NADPH-Cytochrome P450 Reductase and its Potential Role in the Antitumor Effect

• 主要な著者: Haydar Çelik (著者), Emel Arinç (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2009-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

PURPOSE. Idarubicin is a clinically effective synthetic anthracycline analog used in the treatment of several human neoplasms. Anthracyclines have the potential to undergo bioactivation by flavoenzymes to free radicals and thus exert their cytotoxic actions. In this study, our main objective was to...