Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences

• Main Authors: Giulia Costa (Author), Francesca Felicia Caputi (Author), Marcello Serra (Author), Nicola Simola (Author), Laura Rullo (Author), Serena Stamatakos (Author), Fabrizio Sanna (Author), Marc Germain (Author), Maria-Grazia Martinoli (Author), Sanzio Candeletti (Author), Micaela Morelli (Author), Patrizia Romualdi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is an amphetamine-related drug that may damage the dopaminergic nigrostriatal system. To investigate the mechanisms that sustain this toxic effect and ascertain their sex-dependence, we evaluated in the nigrostriatal system of MDMA-treate...