Severe Combined Dyslipidemia With a Complex Genetic Basis

• Main Authors: Ryan Le MD (Author), Minan Abbas MB ChB, FRCPC (Author), Adam D. McIntyre BSc (Author), Robert A. Hegele MD, FRCPC, FACP (Author)
• Format: Book
• Published: SAGE Publishing, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Familial dysbetalipoproteinemia (also known as type 3 hyperlipoproteinemia) is typically associated with homozygosity for the apolipoprotein E2 isoform, but also sometimes with dominant rare missense variants in the APOE gene. Patients present with roughly equimolar elevations of cholest...