Severe Combined Dyslipidemia With a Complex Genetic Basis

• Egile Nagusiak: Ryan Le MD (Egilea), Minan Abbas MB ChB, FRCPC (Egilea), Adam D. McIntyre BSc (Egilea), Robert A. Hegele MD, FRCPC, FACP (Egilea)
• Formatua: Liburua
• Argitaratua: SAGE Publishing, 2019-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Background. Familial dysbetalipoproteinemia (also known as type 3 hyperlipoproteinemia) is typically associated with homozygosity for the apolipoprotein E2 isoform, but also sometimes with dominant rare missense variants in the APOE gene. Patients present with roughly equimolar elevations of cholest...