Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

• Main Authors: Morena Miciaccia (Author), Francesca Rizzo (Author), Antonella Centonze (Author), Gianfranco Cavallaro (Author), Marialessandra Contino (Author), Domenico Armenise (Author), Olga Maria Baldelli (Author), Roberta Solidoro (Author), Savina Ferorelli (Author), Pasquale Scarcia (Author), Gennaro Agrimi (Author), Veronica Zingales (Author), Elisa Cimetta (Author), Simone Ronsisvalle (Author), Federica Maria Sipala (Author), Paola Loguercio Polosa (Author), Cosimo Gianluca Fortuna (Author), Maria Grazia Perrone (Author), Antonio Scilimati (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4-7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue. DIPG is the leading cause of death for pediatric brain tumors due to its infiltrative nature and inoperability. Radiotherapy has only...