Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

• Main Authors: Patrick W. B. Derksen (Author), Tanya M. Braumuller (Author), Eline van der Burg (Author), Marten Hornsveld (Author), Elly Mesman (Author), Jelle Wesseling (Author), Paul Krimpenfort (Author), Jos Jonkers (Author)
• Format: Book
• Published: The Company of Biologists, 2011-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Breast cancer is the most common malignancy in women of the Western world. Even though a large percentage of breast cancer patients show pathological complete remission after standard treatment regimes, approximately 30-40% are non-responsive and ultimately develop metastatic disease. To gen...