Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats

• Main Authors: Venumadhav Janganati (Author), Paloma Salazar (Author), Brian J. Parks (Author), Gregory S. Gorman (Author), Paul L. Prather (Author), Eric C. Peterson (Author), Alexander W. Alund (Author), Jeffery H. Moran (Author), Peter A. Crooks (Author), Lisa K. Brents (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: An active metabolite of buprenorphine (BUP), called norbuprenorphine (NorBUP), is implicated in neonatal opioid withdrawal syndrome when BUP is taken during pregnancy. Therefore, reducing or eliminating metabolism of BUP to NorBUP is a novel strategy that will likely lower total fetal...