Polyphyllin II suppresses cell migration, invasion, and metastasis by inducing cytoskeletal rearrangement through the ROCK1/LIMK/CFL1 pathway in bladder cancer cells

• Main Authors: Zhiyong Liu (Author), Zhonghua Sun (Author), Yuning Xie (Author), Yaxin Shi (Author), Guanghui Pan (Author), Minmin Yu (Author), Zilu Wang (Author), Han Cao (Author), Yang Liu (Author), Quanlai Qiao (Author), Changjing Chen (Author), Xiangdong Xu (Author), Qinlan Song (Author), Zhenguo Wang (Author)
• Format: Book
• Published: Compuscript Ltd, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study was aimed at determining the antimetastatic effect of polyphyllin II (PPII) in bladder cancer (BC) and the underlying mechanisms in vitro and in vivo . Wound healing, Transwell assays, and phalloidin staining were performed to determine the effects of PPII on BC cell migration, invasion,...