Identification of Endogenous Surrogate Ligands for Human P2Y Receptors Through an In Silico Search

• Main Authors: Takeshi Hiramoto (Author), Yosuke Nonaka (Author), Kazuko Inoue (Author), Takefumi Yamamoto (Author), Mariko Omatsu-Kanbe (Author), Hiroshi Matsuura (Author), Keigo Gohda (Author), Norihisa Fujita (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G protein-coupled receptors (GPCRs) are distributed widely throughout the human body, and nearly 50% of current medicines act on a GPCR. GPCRs are considered to consist of seven transmembrane α-helices that form an α-helical bundle in which agonists and antagonists bind. A 3D structure of the target...