Identification of Endogenous Surrogate Ligands for Human P2Y Receptors Through an In Silico Search

• Hoofdauteurs: Takeshi Hiramoto (Auteur), Yosuke Nonaka (Auteur), Kazuko Inoue (Auteur), Takefumi Yamamoto (Auteur), Mariko Omatsu-Kanbe (Auteur), Hiroshi Matsuura (Auteur), Keigo Gohda (Auteur), Norihisa Fujita (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2004-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

G protein-coupled receptors (GPCRs) are distributed widely throughout the human body, and nearly 50% of current medicines act on a GPCR. GPCRs are considered to consist of seven transmembrane α-helices that form an α-helical bundle in which agonists and antagonists bind. A 3D structure of the target...