Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors
We have discovered and synthesized a series of indole-based derivatives as novel sigma-2 (σ2) receptor ligands. Two ligands with high σ2 receptor affinity and subtype selectivity were then radiolabeled with F-18 in good radiochemical yields and purities, and evaluated in rodents. In biodistribution...
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| Main Authors: | , , , , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2022-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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