USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity

• Main Authors: Jaemin Shin (Author), Young Hun Kim (Author), Bin Lee (Author), Jae Ho Chang (Author), Hee Youn Choi (Author), Hoojung Lee (Author), Ki Chan Song (Author), Man Sup Kwak (Author), Ji Eun Choi (Author), Jeon-Soo Shin (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that plays a central role in innate immunity. HMGB1 acts as a late mediator of inflammation when actively secreted in response to inflammatory stimuli. Several post-translational modificati...