p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose γ-Irradiation

• Autores principales: Ines Höfig (Autor), Yashodhara Ingawale (Autor), Michael J. Atkinson (Autor), Heidi Hertlein (Autor), Peter J. Nelson (Autor), Michael Rosemann (Autor)
• Formato: Libro
• Publicado: Hindawi Limited, 2016-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Mesenchymal stem cells (MSCs) are a source of adult multipotent cells important in tissue regeneration. Murine MSCs are known to proliferate poorly in vitro under normoxia. The aim of this study is to analyze the interaction of nonphysiological high oxygen and low-dose γ-irradiation onto growth, sen...