Pharmacokinetics, pharmacodynamics, and safety of frunexian in healthy Chinese volunteer adults: A randomized dose‐escalation phase I study

• Main Authors: Jia‐yu Zhang (Author), Zou‐rong Ruan (Author), Bo Jiang (Author), Dan‐dan Yang (Author), Jia‐ying Wang (Author), Yin Hu (Author), Yong‐rui Wang (Author), Yan‐mei Wang (Author), Yun‐fei Lin (Author), Ling‐ling Wang (Author), Hong‐gang Lou (Author)
• Format: Book
• Published: Wiley, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The purpose of this study was to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of frunexian (formerly known as EP‐7041 and HSK36273) injection, a small molecule inhibitor of activated coagulation factor XI (FXIa), in healthy Chinese adult volunteers. This study was a...