Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo

• Main Authors: Yuanda Wan (Author), Liren Li (Author), Ruilin Chen (Author), Jiajia Han (Author), Qiyun Lei (Author), Zhipeng Chen (Author), Xiaodong Tang (Author), Wenyu Wu (Author), Shuwen Liu (Author), Xingang Yao (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Extracellular vesicles (EVs) have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins (RNPs), owing to their ability to minimize off-target effects and immune responses. However, enhancements are required to boost the efficiency and safety of Cas9 RNP enrichment with...