Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo

• Autors principals: Yuanda Wan (Autor), Liren Li (Autor), Ruilin Chen (Autor), Jiajia Han (Autor), Qiyun Lei (Autor), Zhipeng Chen (Autor), Xiaodong Tang (Autor), Wenyu Wu (Autor), Shuwen Liu (Autor), Xingang Yao (Autor)
• Format: Llibre
• Publicat: Elsevier, 2024-03-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Extracellular vesicles (EVs) have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins (RNPs), owing to their ability to minimize off-target effects and immune responses. However, enhancements are required to boost the efficiency and safety of Cas9 RNP enrichment with...