Functional characteristics of circulating granulocytes in severe congenital neutropenia caused by ELANE mutations

• Main Authors: Qiao Liu (Author), Martina Sundqvist (Author), Wenyan Li (Author), André Holdfeldt (Author), Liang Zhang (Author), Lena Björkman (Author), Johan Bylund (Author), Claes Dahlgren (Author), Cai Wang (Author), Xiaodong Zhao (Author), Huamei Forsman (Author)
• Format: Book
• Published: BMC, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Neutrophils and eosinophils are multifunctional granulocytes derived from common myelocytic-committed progenitor cells. Severe congenital neutropenia 1 (SCN1) caused by ELANE mutations is a rare disease characterized by very low numbers of circulating neutrophils. Little is known...