Overcoming EGFR T790M-based Tyrosine Kinase Inhibitor Resistance with an Allele-specific DNAzyme

• Main Authors: Wei-Yun Lai (Author), Chi-Yuan Chen (Author), Shuenn-Chen Yang (Author), Jer-Yuarn Wu (Author), Cheng-Ju Chang (Author), Pan-Chyr Yang (Author), Konan Peck (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the main therapeutic agents used to treat non-small-cell lung cancer patients harboring EGFR-activating mutations. However, most of these patients will eventually develop resistance, 50% of which are due to a secondary mut...