Coupling Genotyping and Computational Modeling in Prediction of Anti-epileptic Drugs that cause Stevens Johnson Syndrome and Toxic Epidermal Necrolysis for Carrier of HLA-B*15:02

• Main Authors: Lay Kek Teh (Author), Manikandan Selvaraj (Author), Zakaria Bannur (Author), Mohd Ikhwan Mohd Ismail (Author), Hanip Rafia (Author), Wan Chung Law (Author), Sapiah Sapuan (Author), Santhi Puvanarajah (Author), Pakeer Shaik Syed Ali (Author), Mohd Zaki Salleh (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. The importance of HLA-B*15:02 genotyping to avoid carbamazepine induced SJS/TEN and molecular modeling to predict the role of HLA-B*15:0 and AEDs induced SJS/TEN are investigated. Methods. DNA was extracted from eighty-six patients. The patients were genotyped by AS-PCR. Computational model...