Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition

• Main Authors: James J. Beaudoin (Author), Kyunghee Yang (Author), Jeffry Adiwidjaja (Author), Guncha Taneja (Author), Paul B. Watkins (Author), Scott Q. Siler (Author), Brett A. Howell (Author), Jeffrey L. Woodhead (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of the canalicular phospholipid floppase multidrug resistance protein 3 (MDR3) has been implicated in cholestatic drug-induced liver injury (DILI), which is clinically characterized by disrupted bile flow and damage to the biliary epithelium. Reduction in phospholipid excretion, as a cons...