Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives

• मुख्य लेखकों: Maša Sinreih (लेखक), Rebeka Jójárt (लेखक), Zoltán Kele (लेखक), Tomaž Büdefeld (लेखक), Gábor Paragi (लेखक), Erzsébet Mernyák (लेखक), Tea Lanišnik Rižner (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes. The oestrone halides with halogen atoms at both C-2 and C-4 p...