Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives

• প্রধান লেখক: Maša Sinreih (লেখক), Rebeka Jójárt (লেখক), Zoltán Kele (লেখক), Tomaž Büdefeld (লেখক), Gábor Paragi (লেখক), Erzsébet Mernyák (লেখক), Tea Lanišnik Rižner (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes. The oestrone halides with halogen atoms at both C-2 and C-4 p...