Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects

• Main Authors: Dana C. Walters (Author), Erwin E. W. Jansen (Author), Garrett R. Ainslie (Author), Gajja S. Salomons (Author), Madalyn N. Brown (Author), Michelle A. Schmidt (Author), Jean‐Baptiste Roullet (Author), K. M. Gibson (Author)
• Format: Book
• Published: Wiley, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Vigabatrin (VGB; (S)‐(+)/(R)‐(‐) 4‐aminohex‐5‐enoic acid), an antiepileptic irreversibly inactivating GABA transaminase (GABA‐T), manifests use‐limiting ocular toxicity. Hypothesizing that the active S enantiomer of VGB would preferentially accumulate in eye and visual cortex (VC) as one po...