Diagnostic accuracy of a loop-mediated isothermal PCR assay for detection of Orientia tsutsugamushi during acute Scrub Typhus infection.

• Main Authors: Daniel H Paris (Author), Stuart D Blacksell (Author), Pruksa Nawtaisong (Author), Kemajittra Jenjaroen (Author), Achara Teeraratkul (Author), Wirongrong Chierakul (Author), Vanaporn Wuthiekanun (Author), Pacharee Kantipong (Author), Nicholas P J Day (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is an urgent need to develop rapid and accurate point-of-care (POC) technologies for acute scrub typhus diagnosis in low-resource, primary health care settings to guide clinical therapy.In this study we present the clinical evaluation of loop-mediated isothermal PCR assay (LAMP) in the context...