Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

• Main Authors: Giulio Poli (Author), Margherita Lapillo (Author), Vibhu Jha (Author), Nayla Mouawad (Author), Isabella Caligiuri (Author), Marco Macchia (Author), Filippo Minutolo (Author), Flavio Rizzolio (Author), Tiziano Tuccinardi (Author), Carlotta Granchi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoacylglycerol lipase (MAGL) is an attractive therapeutic target for many pathologies, including neurodegenerative diseases, cancer as well as chronic pain and inflammatory pathologies. The identification of reversible MAGL inhibitors, devoid of the side effects associated to prolonged MAGL inacti...