Single-Dose Intravenous Simvastatin Treatment Attenuates Renal Injury in an Experimental Model of Ischemia-Reperfusion in the Rat

• मुख्य लेखकों: Zorica Nešic (लेखक), Zoran Todorovic (लेखक), Radan Stojanovic (लेखक), Gordana Basta-Jovanovic (लेखक), Sanja Radojevic-Škodric (लेखक), Ruzica Velickovic (लेखक), Prabal K. Chatterjee (लेखक), Christoph Thiemermann (लेखक), Milica Prostran (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2006-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The effect of acute pretreatment with a single dose of simvastatin (1 mg/kg, i.v.; 30 min before ischemia) on renal dysfunction caused by ischemia-reperfusion (I/R) injury in the rat was investigated. I/R injury was induced by clamping both renal vascular pedicles for 45 min, followed by 4 h of repe...