Single-Dose Intravenous Simvastatin Treatment Attenuates Renal Injury in an Experimental Model of Ischemia-Reperfusion in the Rat

• Main Authors: Zorica Nešic (Author), Zoran Todorovic (Author), Radan Stojanovic (Author), Gordana Basta-Jovanovic (Author), Sanja Radojevic-Škodric (Author), Ruzica Velickovic (Author), Prabal K. Chatterjee (Author), Christoph Thiemermann (Author), Milica Prostran (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effect of acute pretreatment with a single dose of simvastatin (1 mg/kg, i.v.; 30 min before ischemia) on renal dysfunction caused by ischemia-reperfusion (I/R) injury in the rat was investigated. I/R injury was induced by clamping both renal vascular pedicles for 45 min, followed by 4 h of repe...