Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain

• Main Authors: Leonardo Dini (Author), Martina Del Lungo (Author), Francesco Resta (Author), Michele Melchiorre (Author), Valentina Spinelli (Author), Lorenzo Di Cesare Mannelli (Author), Carla Ghelardini (Author), Annunziatina Laurino (Author), Laura Sartiani (Author), Raffaele Coppini (Author), Guido Mannaioni (Author), Elisabetta Cerbai (Author), Maria Novella Romanelli (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A prominent role of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels has been suggested based on their expression and (dys)function in dorsal root ganglion (DRG) neurons, being likely involved in peripheral nociception. Using HCN blockers as antinociceptive drugs is prevented by t...