Sulfation of afimoxifene, endoxifen, raloxifene, and fulvestrant by the human cytosolic sulfotransferases (SULTs): A systematic analysis

• Main Authors: Ying Hui (Author), Lijun Luo (Author), Lingtian Zhang (Author), Katsuhisa Kurogi (Author), Chunyang Zhou (Author), Yoichi Sakakibara (Author), Masahito Suiko (Author), Ming-Cheh Liu (Author)
• Format: Book
• Published: Elsevier, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous studies demonstrated that sulfate conjugation is involved in the metabolism of three commonly used breast cancer drugs, tamoxifen, raloxifene and fulvestrant. The current study was designed to systematically identify the human cytosolic sulfotransferases (SULTs) that are capable of sulfatin...