Exploitation of Design-of-Experiment Approach for Design and Optimization of Fast-Disintegrating Tablets for Sublingual Delivery of Sildenafil Citrate with Enhanced Bioavailability Using Fluid-Bed Granulation Technique

• Auteurs principaux: Amer S. AlAli (Auteur), Mohammed F. Aldawsari (Auteur), Ahmed Alalaiwe (Auteur), Bjad K. Almutairy (Auteur), Ramadan Al-Shdefat (Auteur), Ismail A. Walbi (Auteur), Mohamed H. Fayed (Auteur)
• Format: Livre
• Publié: MDPI AG, 2021-06-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Sildenafil citrate undergoes first-pass metabolism, resulting in poor oral bioavailability at 25-41% of the administered dose. This study aimed to design and optimize fast-disintegrating tablets for the sublingual delivery of sildenafil citrate to improve bioavailability and facilitate rapid onset o...