Dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic stroke

• Main Authors: P. Y. Povarnina (Author), T. A. Gudasheva (Author), S. B. Seredenin (Author)
• Format: Book
• Published: LLC "Publisher OKI", 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2587-7836; 2686-8830
• Keywords: димерный дипептидный миметик; фактор роста нервов; нейропротекция; ишемический инсульт; окклюзия средней мозговой артерии; dimeric dipeptide mimetic; nerve growth factor; neuroprotection; ischemic stroke; middle cerebral artery occlusion; Pharmacy and materia medica; RS1-441
• Source: Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 34-37 (2016)

Pharmacological activity of dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4, correspondingly GTS-115 and GK-2, was studied in a model of ischemic stroke, induced by transient middle cerebral artery occlusion in rats. The both compounds, at i.p. subchronic administration (0,5-1 mg/kg/day, 7 days, beginning at 4 hours after surgery), significantly reduced cerebral infarct volume as was estimated by morphometry of 2,3,5-triphenyltetrazolium chloride (TTC) -stained brain slices: GTS-115 by 25% and GK-2 by 35%. Mimetic of NGF loop 4 (GK-2), which is the most active compound, was selected for further development as a potential therapeutic agent.