Imperatorin Interferes with LPS Binding to the TLR4 Co-Receptor and Activates the Nrf2 Antioxidative Pathway in RAW264.7 Murine Macrophage Cells

• Main Authors: Mei-Hsuen Huang (Author), Yu-Hsien Lin (Author), Ping-Chiang Lyu (Author), Yi-Chung Liu (Author), Yuan-Shiun Chang (Author), Jing-Gung Chung (Author), Wei-Yong Lin (Author), Wen-Tsong Hsieh (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Imperatorin (IMP) could downregulate several inflammatory transcription factor signaling pathways. Some studies have pointed out that IMP could interfere with toll-like receptor 4 (TLR4) signaling. This study evaluates how IMP interferes with the TLR4 co-receptors signaling through the protein-ligan...