Down-regulation of Toll-like receptor 4 gene expression by short interfering RNA attenuates bone cancer pain in a rat model

• Main Authors: Fang Li (Author), Lei Liu (Author), Ni Ma (Author), Cheng Qiu (Author), Miao Jiang (Author), Na Wang (Author), Ping Yang (Author), Lan Liu (Author), Guang Ren (Author), Jin Zhou (Author), Wei Li (Author)
• Format: Book
• Published: SAGE Publishing, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>This study demonstrates a critical role in CNS innate immunity of the microglial Toll-like receptor 4 (TLR4) in the induction and maintenance of behavioral hypersensitivity in a rat model of bone cancer pain with the technique of RNA...