Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis

• Main Authors: Xian Zhang (Author), Keni Cui (Author), Xiaolu Wang (Author), Yuanyuan Tong (Author), Chihong Liu (Author), Yuechao Zhu (Author), Qidong You (Author), Zhengyu Jiang (Author), Xiaoke Guo (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ulcerative colitis (UC) is an idiopathic inflammatory disease of unknown etiology possibly associated with intestinal inflammation and oxidative stress. Molecular hybridization by combining two drug fragments to achieve a common pharmacological goal represents a novel strategy. The Kelch-like ECH-as...