MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma

• Main Authors: Chase K.A. Neumann (Author), Daniel J. Silver (Author), Varadharajan Venkateshwari (Author), Renliang Zhang (Author), C. Alicia Traughber (Author), Christopher Przybycin (Author), Defne Bayik (Author), Jonathan D. Smith (Author), Justin D. Lathia (Author), Brian I. Rini (Author), J. Mark Brown (Author)
• Format: Book
• Published: Elsevier, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The most common kidney cancer, clear cell renal cell carcinoma (ccRCC), is closely associated with obesity. The "clear cell" variant of RCC gets its name from the large lipid droplets that accumulate in the tumor cells. Although renal lipid metabolism is altered in ccRCC, the me...