Safety and immunogenicity of Nanocovax, a SARS-CoV-2 recombinant spike protein vaccine: Interim results of a double-blind, randomised controlled phase 1 and 2 trial

• Main Authors: Thuy P. Nguyen (Author), Quyet Do (Author), Lan T. Phan (Author), Duc V. Dinh (Author), Hiep Khong (Author), Luong V. Hoang (Author), Thuong V. Nguyen (Author), Hung N. Pham (Author), Men V. Chu (Author), Toan T. Nguyen (Author), Quang D. Pham (Author), Tri M. Le (Author), Tuyen N.T. Trang (Author), Thanh T. Dinh (Author), Thuong V. Vo (Author), Thao T. Vu (Author), Quynh B.P. Nguyen (Author), Vuong T. Phan (Author), Luong V. Nguyen (Author), Giang T. Nguyen (Author), Phong M. Tran (Author), Thuan D. Nghiem (Author), Tien V. Tran (Author), Tien G. Nguyen (Author), Tuynh Q. Tran (Author), Linh T. Nguyen (Author), Anh T. Do (Author), Dung D. Nguyen (Author), Son A. Ho (Author), Viet T. Nguyen (Author), Dung T. Pham (Author), Hieu B. Tran (Author), Son T. Vu (Author), Su X. Hoang (Author), Trung M. Do (Author), Xuan T. Nguyen (Author), Giang Q. Le (Author), Ton Tran (Author), Thang M. Cao (Author), Huy M. Dao (Author), Thao T.T. Nguyen (Author), Uyen Y Doan (Author), Vy T.T. Le (Author), Linh P. Tran (Author), Ngoc M. Nguyen (Author), Ngoc T. Nguyen (Author), Hang T.T. Pham (Author), Quan H. Nguyen (Author), Hieu T. Nguyen (Author), Hang L.K. Nguyen (Author), Vinh T. Tran (Author), Mai T.N. Tran (Author), Truc T.T. Nguyen (Author), Phat T. Ha (Author), Hieu T. Huynh (Author), Khanh D. Nguyen (Author), Ung T. Thuan (Author), Chung C. Doan (Author), Si M. Do (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Background: Nanocovax is a recombinant severe acute respiratory syndrome coronavirus 2 subunit vaccine composed of full-length prefusion stabilized recombinant SARS-CoV-2 spike glycoproteins (S-2P) and aluminium hydroxide adjuvant. Methods: We conducted a dose-escalation, open label trial (...