2-Methoxyestradiol TPGS Micelles Attenuate Cyclosporine A-Induced Nephrotoxicity in Rats through Inhibition of TGF-β1 and p-ERK1/2 Axis

• Main Authors: Mohammed W. Al-Rabia (Author), Mohamed A. Alfaleh (Author), Hani Z. Asfour (Author), Waleed S. Alharbi (Author), Mohamed A. El-Moselhy (Author), Nabil A. Alhakamy (Author), Usama A. Fahmy (Author), Osama A. A. Ahmed (Author), Omar Fahmy (Author), Omar M. Rashad (Author), Abdulmohsin J. Alamoudi (Author), Ashraf B. Abdel-Naim (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The immunosuppressant cyclosporine A (CSA) has been linked to serious renal toxic effects. Although 2-methoxyestradiol (2ME) possesses a wide range of pharmacological abilities, it suffers poor bioavailability after oral administration. The purpose of this study was to evaluate the potential of 2ME...