The design and synthesis of dextran-doxorubicin prodrug-based pH-sensitive drug delivery system for improving chemotherapy efficacy

• Main Authors: Xiaoli Zhang (Author), Tian Zhang (Author), Xianbin Ma (Author), Yajun Wang (Author), Yi Lu (Author), Die Jia (Author), Xiaohua Huang (Author), Jiucun Chen (Author), Zhigang Xu (Author), Feiqiu Wen (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor cells show acidic conditions compared with normal cells, which further inspires scientist to build nanocarrier responsive to tumor microenvironment (TME) for enhancing tumor therapeutic efficacy. Here, we report a pH-sensitive and biocompatible polyprodrug based on dextran-doxorubicin (DOX) pr...