Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta

• Main Authors: Yu-bin He (Author), Hai-zhen Jin (Author), Jin-long Zhao (Author), Chong Wang (Author), Wen-rui Ma (Author), Jie Xing (Author), Xiao-bin Zhang (Author), Yang-yang Zhang (Author), Huang-dong Dai (Author), Nai-shi Zhao (Author), Jian-feng Zhang (Author), Guan-xin Zhang (Author), Jing Zhang (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain less studied. Methods Single-cell RNA sequencing was performed including 5...