Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

• Main Authors: Dario A. Dornbierer (Author), Laurenz Marten (Author), Jovin Mueller (Author), Helena D. Aicher (Author), Michael J. Mueller (Author), Martina Boxler (Author), Michael Kometer (Author), Davor Kosanic (Author), Robin von Rotz (Author), Maxim Puchkov (Author), Thomas Kraemer (Author), Hans-Peter Landolt (Author), Erich Seifritz (Author), Milan Scheidegger (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recently, the Amazonian plant medicine "ayahuasca"-containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such as harmine-has been suggested to exhibit beneficial effects in patients with affective and other mental health disorders. Although ay...