Long‐term daily oral administration of intestinal permeation enhancers is safe and effective in mice

• Main Authors: Katherine C. Fein (Author), John P. Gleeson (Author), Kyle Cochran (Author), Nicholas G. Lamson (Author), Rose Doerfler (Author), Jilian R. Melamed (Author), Kathryn A. Whitehead (Author)
• Format: Book
• Published: Wiley, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Although protein drugs are powerful biologic therapeutics, they cannot be delivered orally because their large size and hydrophilicity limit their absorption across the intestinal epithelium. One potential solution is the incorporation of permeation enhancers into oral protein formulations;...