Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil

• Main Authors: Chaozhuang Shen (Author), Dahu Liang (Author), Xiaohu Wang (Author), Wenxin Shao (Author), Kuo Geng (Author), Xingwen Wang (Author), Hua Sun (Author), Haitang Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Propylthiouracil (PTU) treats hyperthyroidism and thyroid crisis in all age groups. A variety of serious adverse effects can occur during clinical use and require attention to its pharmacokinetic and pharmacodynamic characteristics in various populations.Objective: To provide information...