In Vivo Brain Oxidative Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice

• Main Authors: Qand Agha Nazari (Author), Keita Mizuno (Author), Toshiaki Kume (Author), Yuki Takada-Takatori (Author), Yasuhiko Izumi (Author), Akinori Akaike (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sodium nitroprusside (SNP) is widely used as a potent vasodilator and a nitric oxide (NO) donor, whereas the cytotoxicity of SNP has been well documented. SNP releases several potentially toxic products such as cyanide anion, NO, and iron. We investigated the mechanisms of cell death and motor dysfu...