Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells

• Main Authors: Jarmon G. Lees (Author), Anne M. Kong (Author), Yi C. Chen (Author), Priyadharshini Sivakumaran (Author), Damián Hernández (Author), Alice Pébay (Author), Alexandra J. Harvey (Author), David K. Gardner (Author), Shiang Y. Lim (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human induced pluripotent stem cells (iPSCs) can be differentiated in vitro into bona fide cardiomyocytes for disease modelling and personalized medicine. Mitochondrial morphology and metabolism change dramatically as iPSCs differentiate into mesodermal cardiac lineages. Inhibiting mitochondrial fis...