Edaravone Preserves Coronary Microvascular Endothelial Function After Ischemia/Reperfusion on the Beating Canine Heart In Vivo

• Main Authors: Renan Sukmawan (Author), Toyotaka Yada (Author), Eiji Toyota (Author), Yoji Neishi (Author), Teruyoshi Kume (Author), Yoshiro Shinozaki (Author), Hidezo Mori (Author), Yasuo Ogasawara (Author), Fumihiko Kajiya (Author), Kiyoshi Yoshida (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined whether edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, exerts its protective effect on coronary microvessels after ischemia/reperfusion (I/R) in vivo. Ninety-minute coronary occlusion followed by reperfusion was performed in 16 open-chest dogs with and without...